Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coding sequence polymorphisms among V beta T cell receptor genes.

L R Smith1, A Plaza, P A Singer

  • 1Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

Journal of Immunology (Baltimore, Md. : 1950)
|April 15, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An evaporite sequence from ancient brine recorded in Bennu samples.

Nature·2025
Same author

Anesthetic management of idiopathic intracranial hypertension during pregnancy. A case report.

Revista espanola de anestesiologia y reanimacion..·2024
Same author

Modeling the impact of a supervised consumption site on HIV and HCV transmission among people who inject drugs in three counties in California, USA.

The International journal on drug policy·2024
Same author

Stem cell-based strategies and challenges for production of cultivated meat.

Nature food·2023
Same author

Examining HIV Stigma, Depression, Stress, and Recent Stimulant Use in a Sample of Sexual Minority Men Living with HIV: An Application of the Stigma and Substance Use Process Model.

AIDS and behavior·2021
Same author

Jaundice and a testicular lump: a rare cause of malignant biliary obstruction.

Annals of the Royal College of Surgeons of England·2021
Same journal

Getting on your last nerve: IFNs and resistance to infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

MHC class II on melanoma cells regulates the anti-tumor T cell response.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

ER stress amplifies inflammation via a dual mechanism involving IκBζ-XBP1s synergism and Regnase-1 degradation.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

The V158F polymorphism in human FcγRIIIa/CD16a defines opposing receptor responses when interacting with soluble immune complexes.

Journal of immunology (Baltimore, Md. : 1950)·2026
See all related articles

T-cell receptor (TCR) V beta gene sequencing revealed limited polymorphisms between major histocompatibility complex (MHC) haplotypes. These findings suggest the V beta 6 gene is not the sole cause of collagen-induced arthritis.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Autoimmunity

Background:

  • T-cell receptor (TCR) V beta gene segments differ between TCR V beta a and V beta b haplotypes.
  • Allele-specific autoimmune diseases, such as collagen-induced arthritis, have been reported.
  • The molecular basis of these allele-specific diseases requires further elucidation.

Purpose of the Study:

  • To define coding sequence polymorphisms distinguishing TCR V beta a and V beta b haplotypes.
  • To investigate the role of V beta gene segments in collagen-induced arthritis.

Main Methods:

  • Cloning and sequencing of four V beta gene segments (V beta 1, 3.1, 6, and 10) from V beta a SWR mice.
  • Comparison of sequenced V beta alleles with those from V beta b strains.
  • Analysis of sequence data to identify amino acid differences.

Related Experiment Videos

Main Results:

  • V beta 3.1 and 6 alleles differed by a single amino acid between strains.
  • V beta 1 and 10 alleles differed by 4 and 6 amino acids, respectively.
  • Overall interhaplotypic V beta polymorphisms were found to be limited.

Conclusions:

  • The identified V beta gene polymorphisms are limited between TCR V beta a and V beta b haplotypes.
  • Contrary to previous suggestions, the V beta 6 gene is unlikely to be the sole factor in anticollagen responses.
  • Further research is needed to fully understand the genetic underpinnings of collagen-induced arthritis.