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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Jun 3, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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IGF-1 Antisense Strategies for Cancer Treatment.

Y X Pan1, D D Anthony

  • 1Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH.

Methods in Molecular Medicine
|March 11, 2011
PubMed
Summary
This summary is machine-generated.

This study explores ex vivo gene therapy for cancer using insulin-like growth factor 1 (IGF-1) antisense RNA. This approach targets IGF-1

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Published on: August 25, 2021

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Therapy

Background:

  • Cancer gene therapy employs ex vivo and in vivo gene-transfer techniques.
  • Insulin-like growth factor 1 (IGF-1) and IGF-2 are crucial for cell proliferation and development.
  • IGF-1 and IGF-2 synthesis and activity are prominent during fetal development and downregulated in mature tissues.

Purpose of the Study:

  • To evaluate the applicability of an ex vivo gene therapy approach for cancer treatment.
  • To investigate the use of an IGF-1 antisense RNA strategy.

Main Methods:

  • Utilizing ex vivo gene-transfer methodology.
  • Employing an IGF-1 antisense RNA strategy.

Main Results:

  • The study focuses on the application of ex vivo gene therapy.
  • An IGF-1 antisense RNA strategy is detailed.

Conclusions:

  • Ex vivo gene therapy offers a potential strategy for cancer treatment.
  • Targeting IGF-1 with antisense RNA is a key focus of this research.