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Genetically modified clostridium for gene therapy of tumors
M E Fox1, M J Lemmon, A J Giaccia
1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Methods in Molecular Medicine
|March 11, 2011
Abstract:
Many murine and human tumors contain hypoxic or necrotic regions in which the oxygen tension is abnormally low. For example,>50% of primary tumors of the breast, cervix, and head and neck contain areas that are hypoxic. Because hypoxic regions are not present in normal tissue, this provides the potential for selectively targeting gene therapy to tumor cells.
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