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Direct DNA Injection (p53) into HCC Tumors.

R R Mitry¹, N A Habib

¹Liver Surgery Section, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK.

Methods in Molecular Medicine

|March 11, 2011

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Hepatocellular carcinoma (HCC) is a prevalent global malignancy with a poor prognosis, especially in advanced stages. Current treatments offer limited benefit for most patients diagnosed with liver tumors.

Area of Science:

Hepatology
Oncology
Global Health

Background:

Hepatocellular carcinoma (HCC) ranks among the most frequent cancers worldwide, with approximately 250,000 new cases annually.
The incidence of HCC is notably high in tropical and subtropical regions, affecting sub-Saharan African and Chinese populations disproportionately.
HCC presents a grave prognosis, with advanced-stage patients having a survival expectancy of less than three months.

Purpose of the Study:

To highlight the global burden and poor outcomes associated with Hepatocellular Carcinoma (HCC).
To underscore the limitations of current therapeutic options for advanced liver tumors.

Main Methods:

Literature review and data synthesis on HCC incidence and survival rates.
Analysis of epidemiological data concerning HCC prevalence in specific global regions.

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Last Updated: Jun 3, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

Main Results:

HCC affects 250,000 individuals yearly, with a 4:1 male-to-female ratio.
Advanced HCC cases are often detected beyond the point of curative surgical resection.
Existing therapies demonstrate minimal efficacy for the majority of HCC patients.

Conclusions:

Hepatocellular carcinoma represents a significant global health challenge due to its high incidence and poor prognosis.
The limited success of current treatments necessitates further research into novel therapeutic strategies for liver cancer.