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Biosensor-based methods in clinical diagnosis.

F Aberl¹, C Kößlinger

¹Securetec, Munich, Germany.

Methods in Molecular Medicine

|March 11, 2011

Summary

Metabolic biosensors are increasingly moving from research labs to clinical diagnostics, with glucose sensors being the most economically significant. Other biosensors for analytes like lactate and urea are beginning to be implemented in commercial systems.

Area of Science:

Biomedical Engineering
Clinical Chemistry
Analytical Chemistry

Background:

Clinical laboratories utilize numerous diagnostic parameters, yet few employ biosensor-based methods.
Enzyme and metabolic biosensors dominate the landscape of biochemical sensors in clinical analyzers.
Blood glucose sensors represent the most economically significant application of biosensor technology.

Purpose of the Study:

To review the current status and trends of biosensor applications in clinical diagnostics.
To highlight the transition of metabolic biosensors from academic research to commercial implementation.

Main Methods:

Review of current literature and commercial analytical systems.
Analysis of economically important analytes measured by biosensors.

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Assessment of the implementation status of various metabolic biosensors.

Main Results:

A small fraction of clinical laboratory parameters are measured using biosensor technology.
Enzyme/metabolic biosensors are prevalent in integrated clinical analyzers.
Blood glucose biosensors are the leading economic driver, with lactate and urea sensors emerging.

Conclusions:

Metabolic biosensors are gradually transitioning from academic research settings into practical clinical laboratory use.
The development and commercialization of biosensors for various analytes are expanding beyond glucose monitoring.