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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Fluid Mosaic Model01:34

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The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.LipidsThe most...

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A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
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Published on: February 24, 2023

Fluid-induced osteolysis: modelling and experiments.

Lars Johansson1, Ulf Edlund, Anna Fahlgren

  • 1Department of Management and Engineering, Linköping University, Linköping, Sweden. lars.johansson@liu.se

Computer Methods in Biomechanics and Biomedical Engineering
|March 11, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a new model for bone resorption, linking fluid flow at the bone-soft tissue interface to increased osteoclast activity and bone loss. Findings support a novel pathway influencing bone remodeling.

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Published on: February 17, 2018

Area of Science:

  • Biomechanical Engineering
  • Cell Biology
  • Orthopedics

Background:

  • Bone remodeling is traditionally linked to mechanical stress, strain, or energy density.
  • Existing models do not fully account for the role of fluid dynamics at the bone-soft tissue interface.

Purpose of the Study:

  • To develop and validate a computational model for bone resorption driven by fluid flow.
  • To investigate the influence of fluid flow parameters on osteoclast activity and bone resorption.

Main Methods:

  • Development of a computational model to calculate bone resorption stimulated by fluid flow.
  • Experimental validation using a rat model subjected to controlled fluid flow conditions.
  • Comparison of model predictions with experimental outcomes.

Main Results:

  • The developed model successfully predicts bone resorption influenced by fluid flow.
  • Experimental data supports the hypothesis that fluid flow parameters can stimulate osteoclast-mediated bone removal.
  • Identified a potential new pathway for bone remodeling.

Conclusions:

  • Fluid flow at the bone-soft tissue interface is a significant factor in bone resorption.
  • The new model provides a basis for understanding and potentially manipulating bone remodeling processes.
  • This research opens avenues for therapeutic interventions targeting bone loss related to fluid dynamics.