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A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as

Ayhan Dogukan1, Mehmet Tuzcu, Can Ali Agca

  • 1Department of Nephrology, School of Medicine, Firat University, Elazig, Turkey.

Nutrition and Cancer
|March 11, 2011
PubMed

Insights

Tomato lycopene complex protects against cisplatin-induced nephrotoxicity by reducing oxidative stress and lipid peroxidation in rats. This dietary antioxidant intervention improved kidney function markers and modulated key protein expressions, suggesting a therapeutic potential.

Area of Science:

  • Biochemistry
  • Toxicology
  • Nutritional Science

Background:

  • Cisplatin chemotherapy is associated with significant kidney damage, primarily due to increased oxidative stress.
  • Lycopene, a potent antioxidant found in tomatoes, is being investigated for its potential protective effects against drug-induced toxicity.

Purpose of the Study:

  • To investigate the protective effects of a tomato lycopene complex against cisplatin-induced nephrotoxicity and lipid peroxidation in a rat model.
  • To evaluate the impact of tomato lycopene complex on oxidative stress markers and key protein expressions in cisplatin-treated rats.

Main Methods:

  • Male Wistar rats were divided into four groups: control, tomato lycopene complex alone, cisplatin alone, and cisplatin plus tomato lycopene complex.
  • Biochemical parameters (serum urea-N, creatinine), lipid peroxidation markers (MDA, 8-isoprostane), and protein expressions (Bax, Bcl-2, HSP60, HSP70) were analyzed.
  • Lycopene levels in serum were measured to confirm supplementation.

Main Results:

  • Cisplatin significantly increased serum urea-N and creatinine, decreased body weight, and elevated renal MDA and 8-isoprostane levels.
  • Tomato lycopene complex administration significantly reduced these cisplatin-induced detrimental effects, including preventing the rise in MDA and 8-isoprostane.
  • The complex also modulated the expression of apoptosis-related proteins (Bax, Bcl-2) and heat shock proteins (HSP60, HSP70), indicating reduced cellular damage.

Conclusions:

  • Tomato lycopene complex demonstrates significant protective effects against cisplatin-induced nephrotoxicity and lipid peroxidation in rats.
  • The findings suggest that lycopene's antioxidant properties contribute to mitigating cisplatin-induced kidney damage by reducing oxidative stress and influencing cell survival pathways.

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