Related Experiment Video

Updated: Jun 3, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

[Pneumocystis pneumonia in a renal transplant recipient]

Soykan Özkoç1, Tonay İnceboz, Aykut Sıfıl

  • 1Dokuz Eylül Üniversitesi Tıp Fakültesi, Parazitoloji Anabilim Dalı, İzmir, Türkiye. soykan.ozkoc@deu.edu.tr

Turkiye Parazitolojii Dergisi
|March 11, 2011
PubMed

Insights

Pneumocystis pneumonia (PCP), an opportunistic infection, can occur even with prophylaxis in immunocompromised patients. This case highlights the importance of vigilant monitoring and treatment for Pneumocystis jirovecii in transplant recipients.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Pneumocystis pneumonia (PCP) is a severe opportunistic infection caused by Pneumocystis jirovecii.
  • Renal transplant recipients are particularly vulnerable to opportunistic infections due to immunosuppression.

Observation:

  • A 23-year-old male renal transplant recipient developed pneumonia.
  • Pneumocystis jirovecii was identified in bronchoalveolar lavage samples using Giemsa, methenamine-silver, and Toluidine-O staining.
  • The patient had been receiving prophylaxis for PCP post-transplantation.

Findings:

  • The patient was diagnosed with Pneumocystis pneumonia.
  • Successful treatment was achieved with 21 days of trimethoprim-sulfamethoxazole (TMP-SMX) therapy.
  • Recovery was observed within 21 days of treatment initiation.

Implications:

  • This case underscores the importance of vigilant monitoring for PCP in immunocompromised patients, even those on prophylaxis.
  • Early detection and appropriate treatment are crucial for managing PCP in transplant recipients.
  • The study emphasizes the persistent risk of P. jirovecii infection in immunocompromised populations.

More Related Videos

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...