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Automated immunoassay for reliable measurement of sex hormone binding globulin (SHBG)
1Department of Laboratory Medicine, Cliniques Universitaires St-Luc, 1200 Brussels, Belgium. damien.gruson@uclouvain.be
Background:
Sex hormone binding globulin (SHBG) is important for the transport and regulation of distribution of sex steroids.
Methods:
The performance of the Architect SHBG automated immunoassay in comparison to radioimmunoassay was evaluated using 62 patient specimens. Furthermore, specimen from 100 healthy individuals were used to establish a preliminary reference interval for this automated assay.
Results:
The assay has demonstrated overall good analytical performance and was significantly correlated with the reference method.
Conclusions:
The Architect SHBG assay is a good method for routine measurement of SHBG circulating levels.
