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Monitoring Protein Adsorption with Solid-state Nanopores
Published on: December 2, 2011
Dynamics of colloids in single solid-state nanopores.
L Bacri1, A G Oukhaled, B Schiedt
1LAMBE UMR CNRS 8587, Evry and Cergy-Pontoise University, France.
The Journal of Physical Chemistry. B
|March 12, 2011
Summary
We studied charged colloid dynamics in solid-state nanopores using applied voltage. Colloid presence alters pore resistance, with event frequency and duration depending on electrical force and voltage, revealing distinct governing mechanisms.
Area of Science:
- Physics
- Materials Science
- Colloid Science
Background:
- Solid-state nanopores are crucial for single-molecule analysis.
- Understanding charged colloid behavior in confined geometries is essential for various applications.
Purpose of the Study:
- To investigate the dynamics of single electrically charged colloids translocating through solid-state nanopores.
- To determine the influence of applied voltage and electrical force on colloid transport.
Main Methods:
- Utilized solid-state nanopores to monitor ionic current changes.
- Applied varying voltages to electrically charged colloids and analyzed current blockade events.
- Correlated event characteristics (duration, frequency) with applied electrical force.
Main Results:
- Colloid presence significantly alters nanopore resistance.
- Ionic current blockade magnitude increases with voltage, then plateaus.
- Observed distinct short and long current blockade events, with long events correlating to translocations.
- Event frequency increases exponentially with voltage, while dwelling time shows complex voltage-dependent behavior.
- The ratio of long events increases with electrical force.
Conclusions:
- Nanopore resistance is sensitive to single colloid presence.
- Colloid dynamics are governed by a transition from free-energy barrier effects at low/medium voltages to electrophoresis at high voltages.
- The study provides insights into voltage-controlled transport of charged particles in nanopores.
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