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Updated: Jun 3, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

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Published on: December 2, 2011

Dynamics of colloids in single solid-state nanopores.

L Bacri1, A G Oukhaled, B Schiedt

  • 1LAMBE UMR CNRS 8587, Evry and Cergy-Pontoise University, France.

The Journal of Physical Chemistry. B
|March 12, 2011
PubMed
Summary
This summary is machine-generated.

We studied charged colloid dynamics in solid-state nanopores using applied voltage. Colloid presence alters pore resistance, with event frequency and duration depending on electrical force and voltage, revealing distinct governing mechanisms.

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Area of Science:

  • Physics
  • Materials Science
  • Colloid Science

Background:

  • Solid-state nanopores are crucial for single-molecule analysis.
  • Understanding charged colloid behavior in confined geometries is essential for various applications.

Purpose of the Study:

  • To investigate the dynamics of single electrically charged colloids translocating through solid-state nanopores.
  • To determine the influence of applied voltage and electrical force on colloid transport.

Main Methods:

  • Utilized solid-state nanopores to monitor ionic current changes.
  • Applied varying voltages to electrically charged colloids and analyzed current blockade events.
  • Correlated event characteristics (duration, frequency) with applied electrical force.

Main Results:

  • Colloid presence significantly alters nanopore resistance.
  • Ionic current blockade magnitude increases with voltage, then plateaus.
  • Observed distinct short and long current blockade events, with long events correlating to translocations.
  • Event frequency increases exponentially with voltage, while dwelling time shows complex voltage-dependent behavior.
  • The ratio of long events increases with electrical force.

Conclusions:

  • Nanopore resistance is sensitive to single colloid presence.
  • Colloid dynamics are governed by a transition from free-energy barrier effects at low/medium voltages to electrophoresis at high voltages.
  • The study provides insights into voltage-controlled transport of charged particles in nanopores.