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Intrarenal adenosine prevents hyperfiltration induced by atrial natriuretic factor
S Angielski1, M Redlak, M Szczepańska-Konkel
1Department of Clinical Biochemistry, Medical Academy, Gdańsk, Poland.
Mineral and Electrolyte Metabolism
|January 1, 1990
Summary
Renal adenosine restrains hyperfiltration induced by atrial natriuretic factor (ANF) and glucagon. Depleting adenosine potentiates these hormones' effects on glomerular filtration rate (GFR).
Area of Science:
- Nephrology
- Renal Physiology
- Endocrinology
Background:
- Atrial natriuretic factor (ANF) and glucagon induce hyperfiltration.
- Increased urinary adenosine accompanies this hyperfiltration.
Purpose of the Study:
- To investigate the role of intrarenal adenosine in hormone-induced glomerular hyperfiltration.
- To determine if adenosine inhibits ANF and glucagon effects on GFR.
Main Methods:
- Administered ANF and glucagon to rats, measuring GFR and urinary adenosine.
- Used adenosine deaminase to deplete intrarenal adenosine.
- Assessed GFR and renal plasma flow before and after adenosine deaminase treatment.
Main Results:
- ANF and glucagon increased GFR and urinary adenosine.
- Adenosine deaminase treatment reduced plasma and urinary adenosine without altering basal GFR.
- Adenosine depletion potentiated and prolonged the hyperfiltration effects of ANF and glucagon.
Conclusions:
- Renal adenosine does not decrease basal GFR.
- Adenosine acts as an inhibitor of hyperfiltration during hormonal stimulation.
- Endogenous adenosine restrains ANF- or glucagon-induced hyperfiltration.