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Updated: Jun 3, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
A simple, nontoxic iron system for the allylation of zinc enolates
Gopala K Jarugumilli1, Silas P Cook
1Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
Abstract:
Diiron nonacarbonyl in combination with triphenylphosphine has been identified as a low-cost and environmentally benign catalyst system for the allylation of zinc enolates generated in situ from copper-catalyzed asymmetric conjugate addition reactions. The catalyst system provides the allylated product in modest to good yields at room temperature with unprecedented diastereoselectivity in cyclic enone systems. While triphenylphosphine was uniquely effective among the investigated ligands, the exact nature of the active catalytic species remains unknown.
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