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The coagulopathy of cardiopulmonary bypass

Martin W Besser1, Andrew A Klein

  • 1Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.

Critical Reviews in Clinical Laboratory Sciences
|March 12, 2011
PubMed

Insights

This review details cardiopulmonary bypass (CPB) coagulopathy, covering its history, CPB circuit components, and current knowledge on pathogenesis, prevention, and treatment strategies.

Area of Science:

  • Cardiovascular Surgery
  • Hematology

Background:

  • Cardiopulmonary bypass (CPB) is frequently associated with coagulopathy, a significant clinical challenge.
  • Numerous publications exist, necessitating a consolidated overview of the topic.

Purpose of the Study:

  • To provide a comprehensive review of cardiopulmonary bypass (CPB) coagulopathy.
  • To summarize the history, components, pathogenesis, prevention, and treatment of CPB-induced coagulopathy.
  • To discuss coagulation monitoring and transfusion support in the context of CPB.

Main Methods:

  • Literature review synthesizing existing publications on CPB coagulopathy.
  • Analysis of historical and current CPB technologies and supportive care.
  • Emphasis on near-patient testing for intra- and postoperative coagulation monitoring.

Main Results:

  • CPB circuits have evolved significantly, impacting coagulopathy.
  • Understanding of CPB coagulopathy pathogenesis, prevention, and treatment has advanced.
  • Near-patient testing and updated transfusion strategies are crucial.

Conclusions:

  • Effective management of CPB coagulopathy requires understanding its multifaceted nature.
  • Technological advancements and monitoring techniques have improved patient care.
  • A comprehensive approach to coagulation management is essential for CPB patients.

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