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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 3, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
13:58

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

Embryonic stem cell extracts: use in differentiation and reprogramming.

Jinnuo Han1, Kuldip Sidhu

  • 1Stem Cell Laboratory, School of Psychiatry, Faculty of Medicine, The University of New South Wales, Sydney, Australia.

Regenerative Medicine
|March 12, 2011
PubMed
Summary
This summary is machine-generated.

Embryonic stem cells are key to reprogramming somatic cells into patient-specific stem cells. This advance holds promise for regenerative medicine, potentially reducing transplant rejection for diseases like Parkinson's and diabetes.

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Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
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Published on: January 19, 2020

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Cellular reprogramming

Background:

  • Stem cells possess self-renewal and differentiation capabilities.
  • Embryonic stem cells (ESCs) are crucial for directed differentiation in regenerative medicine.
  • Cellular reprogramming converts somatic cells to a pluripotent state, offering autologous stem cell sources.

Purpose of the Study:

  • To introduce stem cells and their properties.
  • To discuss the role of ESCs in somatic cell reprogramming and differentiation.
  • To explore the application of ESC extracts in reprogramming and transdifferentiation.

Main Methods:

  • Review of existing literature on stem cell differentiation and reprogramming.
  • Discussion of ESCs' application in inducing reprogramming.
  • Analysis of ESC extracts' role in transdifferentiation.

Main Results:

  • ESCs can be utilized for directed differentiation into specific cell types.
  • Reprogramming somatic cells using ESCs offers a potential source of autologous stem cells.
  • ESC extracts show potential in inducing reprogramming and transdifferentiation.

Conclusions:

  • Successful application of ESCs in reprogramming and differentiation could lead to patient-specific cell therapies.
  • This approach may significantly decrease the risk of immune rejection in cell transplantation.
  • Potential applications include treating debilitating diseases such as Parkinson's, Alzheimer's, and diabetes.