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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...

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Related Experiment Video

Updated: Jun 3, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Addressing concerns about cisplatin application during pregnancy.

Malgorzata Lanowska1, Christhardt Köhler, Peter Oppelt

  • 1Department of Gynecology, Charité Universitätsmedizin, Berlin, Germany. malgorzata.lanowska@charite.de

Journal of Perinatal Medicine
|March 12, 2011
PubMed
Summary
This summary is machine-generated.

This study found that cisplatin chemotherapy during pregnancy for cervical cancer resulted in lower concentrations in fetal tissues and normal infant development. However, cisplatin was detected in breast milk, advising against breastfeeding.

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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Area of Science:

  • Oncology
  • Maternal-Fetal Medicine
  • Pharmacology

Background:

  • Cervical cancer during pregnancy presents significant treatment challenges.
  • Cisplatin is a recommended chemotherapy agent for managing cancer progression in pregnant patients.

Observation:

  • This study tracked eight pregnant patients with cervical cancer undergoing cisplatin chemotherapy.
  • Measurements of cisplatin concentration were taken in maternal blood, umbilical cord blood, amniotic fluid, and breast milk.
  • Infant development was monitored postpartum.

Findings:

  • Cisplatin concentrations in umbilical cord blood and amniotic fluid were significantly lower than in maternal blood (31-65% and 13-42%, respectively).
  • Nine healthy infants were born with normal developmental outcomes.
  • Cisplatin was detected in breast milk at 1-10% of maternal blood concentrations.

Implications:

  • The findings support the use of cisplatin during pregnancy for cervical cancer due to lower fetal exposure and normal infant development.
  • Breastfeeding is not recommended due to detectable cisplatin levels in breast milk.