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Pan-insulin allergy and severe lipoatrophy complicating Type 2 diabetes
A N Tavare1, H J Doolittle, R Baburaj
1Department of Diabetes and Endocrinology, The Hillingdon Hospital, Uxbridge, UK. aniket.tavare@gmail.com
Summary
Insulin allergy and lipoatrophy are rare but serious complications of insulin therapy. This case highlights challenges in managing diabetes when these conditions arise, impacting glycemic control.
Area of Science:
- Endocrinology
- Immunology
- Dermatology
Background:
- Insulin allergy is a rare adverse reaction to insulin therapy.
- Localized lipoatrophy is a known complication of subcutaneous insulin injections.
Observation:
- A 53-year-old female with Type 2 diabetes presented with allergic symptoms to all insulin types.
- Severe lipoatrophy developed at insulin injection sites on the abdomen and thighs.
Findings:
- The patient experienced suboptimal glycemic control due to insulin allergy and lipoatrophy.
- All tested insulin preparations elicited local allergic-type symptoms.
Implications:
- Insulin allergy and lipoatrophy can significantly complicate diabetes management.
- Understanding pathophysiological mechanisms is crucial for effective treatment strategies.
- A stepwise management approach is recommended for these rare complications.
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