Related Experiment Video

Updated: Jun 3, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Surveillance for invasive meningococcal disease in children, US-Mexico border, 2005-2008

Enrique Chacon-Cruz1, David E Sugerman, Michele M Ginsberg

  • 1General Hospital of Tijuana, Tijauna, Mexico. echacon88@hotmail.com

Emerging Infectious Diseases
|March 12, 2011
PubMed

Insights

Pediatric invasive meningococcal disease in Tijuana and San Diego showed similar incidence and fatality rates. Most Tijuana cases were preventable with vaccines, highlighting a public health opportunity.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Invasive meningococcal disease (IMD) poses a significant global health threat, particularly in pediatric populations.
  • Understanding regional variations in IMD epidemiology is crucial for targeted prevention strategies.
  • Cross-border surveillance can reveal disease transmission patterns and inform public health interventions.

Purpose of the Study:

  • To compare the epidemiology of pediatric invasive meningococcal disease between Tijuana, Mexico, and San Diego County, California, USA.
  • To assess the potential impact of vaccination on reducing IMD cases in Tijuana.
  • To inform cross-border public health strategies for meningococcal disease prevention.

Main Methods:

  • Retrospective review of confirmed pediatric invasive meningococcal disease cases.
  • Data collection from Tijuana, Mexico, and San Diego County, California, USA.
  • Analysis of incidence rates, fatality rates, and serogroup distribution.

Main Results:

  • Incidence and fatality rates of pediatric IMD were comparable between Tijuana and San Diego from 2005-2008.
  • Serogroup distribution analysis indicated that a majority of IMD cases in Tijuana were potentially preventable by existing vaccines.
  • The findings suggest similar disease burden and vaccine-preventable potential across the border.

Conclusions:

  • Pediatric invasive meningococcal disease surveillance and outcomes are similar in Tijuana and San Diego.
  • Vaccine-preventable serogroups are prevalent in Tijuana, indicating a significant opportunity for public health intervention.
  • Cross-border collaboration is essential for effective control of meningococcal disease in adjacent regions.

More Related Videos

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection05:55

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

A CFSE-based Assay to Study the Migration of Murine Skin Dendritic Cells into Draining Lymph Nodes During Infection with Mycobacterium bovis Bacille Calmette-Guérin07:14

A CFSE-based Assay to Study the Migration of Murine Skin Dendritic Cells into Draining Lymph Nodes During Infection with Mycobacterium bovis Bacille Calmette-Guérin

Published on: October 9, 2016

Related Concept Videos

Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.