Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet kinetics in patients with atherosclerosis.

H Sinzinger1, I Virgolini, P Fitscha

  • 1Department of Nuclear Medicine, University of Vienna, Ludwig Boltzmann-Institute for Nuclear Medicine, Austria.

Thrombosis Research
|February 15, 1990
PubMed
Summary

Platelet survival is significantly reduced in patients with atherosclerosis. While imaging showed no differences, altered thromboxane B2 metabolism suggests increased platelet activation in these individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isradipine increases vascular prostaglandin I2-formation while the thromboxane B2-synthesis is diminished.

Thrombosis research·1995
Same author

Passive smoking and cardiovascular risk.

Archives of internal medicine·1995
Same author

Gamma irradiation is not a novel approach to inhibit neointimal hyperplasia after arterial injury.

Stroke·1995
Same author

Arterial wall rather than platelets is responsible for diminished thrombogenicity during isradipine therapy.

Journal of cardiovascular pharmacology·1995
Same author

Evidence for lipid regression in humans in vivo performed by 123iodine-low-density lipoprotein scintiscanning.

Annals of the New York Academy of Sciences·1995
Same author

[1995 consensus guidelines for cholesterol. Society of Physicians in Vienna].

Wiener klinische Wochenschrift·1995

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Nuclear Medicine

Background:

  • Atherosclerosis is a complex disease affecting arteries.
  • Platelet activation plays a crucial role in thrombotic events associated with atherosclerosis.

Purpose of the Study:

  • To investigate platelet kinetics and activation markers in patients with clinically manifest atherosclerosis.
  • To assess the utility of radiolabeled autologous platelets in visualizing atherosclerotic disease.

Main Methods:

  • Autologous platelets were labeled with Indium-111 oxine in 12 atherosclerosis patients and 6 controls.
  • Platelet half-life was determined using gamma camera imaging.
  • Serum and plasma thromboxane B2 levels and arachidonic acid conversion were measured.

Related Experiment Videos

Main Results:

  • Platelet half-life was significantly shorter (p < 0.01) in patients with atherosclerosis.
  • No significant differences in platelet distribution were observed via gamma imaging.
  • Plasma thromboxane B2 showed a trend towards increase, and conversion of arachidonic acid to thromboxane B2 was elevated in atherosclerotic patients.

Conclusions:

  • Atherosclerosis is associated with accelerated platelet turnover.
  • Despite normal imaging, altered thromboxane B2 metabolism indicates increased platelet activation in atherosclerosis.