Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Diabetic Ketoacidosis ll: Pathophysiology01:22

Diabetic Ketoacidosis ll: Pathophysiology

Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Capitalising (on) industrial epidemics: examining the influence of the 'Big Three' asset managers on corporate governance in key health-harming commodity industries.

Globalization and health·2026
Same author

Effects of the Sodium-Glucose Cotransporter-2 Inhibitor Velagliflozin on Insulin Concentrations in Horses With Insulin Dysregulation.

Journal of veterinary internal medicine·2025
Same author

Identifying the factors influencing the development of bilateral investment treaties with health safeguards: a Machine Learning-based link prediction approach.

Journal of computational social science·2024
Same author

Investigation of Veterinary Student and Faculty Perspectives of Factors Affecting In-Person Lecture Attendance.

Journal of veterinary medical education·2024
Same author

Gender Distribution of Course Material Authors in a Doctor of Veterinary Medicine Program.

Journal of veterinary medical education·2024
Same author

Comparison of a customized glycemic pellets challenge with the oral sugar test to measure glycemic and insulinemic responses in horses.

Journal of veterinary internal medicine·2024

Related Experiment Video

Updated: Jun 3, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
10:31

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Equine metabolic syndrome.

Nicholas Frank1

  • 1Department of Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996, USA. nfrank@utk.edu

The Veterinary Clinics of North America. Equine Practice
|March 12, 2011
PubMed
Summary
This summary is machine-generated.

Equine metabolic syndrome (EMS) shares features with human metabolic syndrome (MetS), including obesity and insulin resistance. However, EMS primarily involves laminitis, a distinct equine health concern.

More Related Videos

High-Resolution Fluoro-Respirometry of Equine Skeletal Muscle
07:39

High-Resolution Fluoro-Respirometry of Equine Skeletal Muscle

Published on: February 3, 2023

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Related Experiment Videos

Last Updated: Jun 3, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
10:31

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

High-Resolution Fluoro-Respirometry of Equine Skeletal Muscle
07:39

High-Resolution Fluoro-Respirometry of Equine Skeletal Muscle

Published on: February 3, 2023

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Area of Science:

  • Veterinary Medicine
  • Equine Health
  • Endocrinology

Background:

  • Equine metabolic syndrome (EMS) concept emerged in 2002.
  • EMS has evolved and was recently defined by the American College of Veterinary Internal Medicine.
  • Human metabolic syndrome (MetS) involves cardiovascular risk factors like obesity, insulin resistance, and hypertension.

Purpose of the Study:

  • To define and differentiate Equine Metabolic Syndrome (EMS) from human Metabolic Syndrome (MetS).
  • To highlight the key features and primary concerns associated with EMS.

Main Methods:

  • Conceptual review and comparison of EMS and MetS definitions.
  • Analysis of shared and distinct clinical features.

Main Results:

  • EMS shares features with MetS, such as increased adiposity and insulin resistance (IR).
  • A key distinction is that laminitis is the primary disease of concern in EMS.

Conclusions:

  • EMS is a distinct syndrome in horses with shared metabolic characteristics with human MetS.
  • Laminitis is the defining clinical manifestation of Equine Metabolic Syndrome.