Related Experiment Video

Updated: Jun 3, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children

Samuel H Wedes1, Weijia Wu, Suzy A A Comhair

  • 1Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.

The Journal of Pediatrics
|March 12, 2011
PubMed

Insights

Urinary bromotyrosine, a marker of eosinophil activity, effectively tracks asthma control in children. High levels predict a significantly increased risk of future asthma exacerbations.

Area of Science:

  • Biochemistry
  • Pulmonology
  • Pediatrics

Background:

  • Asthma control is crucial for managing pediatric respiratory health.
  • Eosinophil-mediated inflammation contributes to asthma severity.
  • Noninvasive biomarkers are needed to monitor asthma control and predict exacerbations.

Purpose of the Study:

  • To evaluate urinary bromotyrosine as a noninvasive marker for tracking asthma control in children.
  • To assess the predictive value of urinary bromotyrosine for future asthma exacerbations.

Main Methods:

  • Recruited children with asthma for clinic visits.
  • Collected urine samples for bromotyrosine analysis.
  • Gathered spirometry, exhaled nitric oxide, and Asthma Control Questionnaire data.
  • Followed up participants for 6 weeks to monitor asthma exacerbations.

Main Results:

  • Urinary bromotyrosine levels significantly correlated with asthma control scores (Asthma Control Questionnaire).
  • High baseline bromotyrosine levels were associated with inadequately controlled asthma (18.1-fold increased likelihood).
  • High bromotyrosine levels predicted a greater risk of asthma exacerbations within 6 weeks (4.0-fold increased likelihood).

Conclusions:

  • Urinary bromotyrosine serves as a valuable noninvasive biomarker for assessing asthma control in pediatric patients.
  • This marker effectively predicts the risk of subsequent asthma exacerbations, aiding in proactive management strategies.
Abstract

More Related Videos

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications08:41

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

Published on: July 14, 2017

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

Related Concept Videos

Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.