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Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases

Martina Vendrame1, Annapurna Poduri, Tobias Loddenkemper

  • 1Epilepsy and Clinical Neurophysiology, Children's Hospital Boston, Boston, MA 02115, USA.

Epileptic Disorders : International Epilepsy Journal with Videotape
|March 12, 2011
PubMed

Insights

Rufinamide (RUF) shows promise for treating malignant migrating partial seizures of infancy (MMPEI). Two infants experienced over 50% seizure reduction, offering hope for this rare, severe epilepsy syndrome.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Pharmacology

Background:

  • Malignant migrating partial seizures of infancy (MMPEI) is a severe epilepsy syndrome with early onset, multiple seizure types, and poor prognosis.
  • Current treatment options for MMPEI are limited, with high rates of drug resistance.

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