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Updated: Jun 3, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Evaluation of oxidant and antioxidant status in infants with hyperbilirubinemia and kernicterus
Murat Doğan1, Erdal Peker, Ercan Kirimi
1Department of Pediatrics, School of Medicine, Yuzuncu Yil University, Van, Turkey. doganmurat.md@gmail.com
Objective:
The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status.
Patients:
The study includes 69 full-term newborns (neonates with hyperbilirubinemia needing phototherapy [Group 1, n = 36] and neonates with kernicterus [Group 2, n = 33]) and 25 age-matched healthy newborn.
Results:
Plasma total antioxidant capacity (TAC) and serum total oxidant status (TOS) were significantly higher in Groups 1 and 2 than the control group. There was a significant difference between Group 1 and control cases for malondialdehyde (MDA; p < 0.001). Total free sulfhydryl group (TTHI) values were significantly elevated in Group 1 compared to Group 2 and control cases. Correlation analysis showed that the correlation between total bilirubin (TB) and TAC, TOS, MDA and oxidative stress index may be expressed by a quadratic curve. After phototherapy, a statistically significant increase in nitrite level was observed.
Conclusion:
We demonstrated that the relationship between serum TB and antioxidants and oxidative stress could be expressed by a quadratic correlation curve.
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