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[Quinolones: confirmations and promises].

V De Marino1, A Marino

  • 1II Facoltà di Medicina e Chirurgia dell'Università di Napoli.

La Clinica Terapeutica
|January 15, 1990
PubMed
Summary
This summary is machine-generated.

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This review covers new and old quinolones, detailing their pharmacokinetics and clinical utility. The discussion highlights their bactericidal properties and the rare development of bacterial resistance.

Area of Science:

  • Pharmacology
  • Microbiology
  • Medicinal Chemistry

Context:

  • Quinolones represent a significant class of synthetic antibacterial agents.
  • Understanding their pharmacokinetic profiles is crucial for effective therapeutic use.
  • The emergence of antimicrobial resistance necessitates ongoing evaluation of antibiotic efficacy.

Purpose:

  • To review the pharmacokinetics of both established and novel quinolone antibiotics.
  • To assess the clinical usefulness of quinolones based on their bactericidal activity.
  • To examine the incidence and mechanisms of resistance development to quinolones.

Summary:

  • This review synthesizes current knowledge on quinolone pharmacokinetics, encompassing older and newer generations.
  • Clinical utility is evaluated, emphasizing the potent bactericidal effects of these agents.

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  • The low propensity for resistance development among quinolones is a key finding.

    • Impact:

    • Provides a comprehensive overview for clinicians and researchers regarding quinolone antibiotics.
    • Informs therapeutic strategies by highlighting the favorable pharmacokinetic and bactericidal profiles.
    • Underscores the continued relevance of quinolones in combating bacterial infections due to low resistance rates.