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Updated: Jun 3, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Retrospective analysis of basal cell carcinoma
Sibel Hakverdi1, Didar D Balci, Cigdem A Dogramaci
1Department of Pathology, Mustafa Kemal University, Faculty of Medicine, Hatay, Turkey. hakverdisibel@yahoo.com
Indian Journal of Dermatology, Venereology and Leprology
|March 12, 2011
Summary
Basal cell carcinoma (BCC) subtypes vary by patient age, sex, and anatomical location. Infiltrative BCCs have higher rates of positive surgical margins and recurrence, especially in difficult-to-treat areas.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Basal cell carcinoma (BCC) is the most common cancer in fair-skinned populations globally.
- Understanding BCC characteristics is crucial for effective treatment and management.
Purpose of the Study:
- To analyze gender and age-specific incidence of basal cell carcinoma (BCC) histopathologic subtypes.
- To classify BCCs by anatomical location, invasion depth, and size.
- To determine the relationship between BCC subtypes and surgical excision margins.
Main Methods:
- Retrospective analysis of 197 BCCs diagnosed between 2005 and 2010.
- Inclusion criteria: histopathological diagnosis of BCC confirmed by two pathologists.
- Data collected: patient sex, age, tumor location, histological subtype, invasion depth, and size.
Main Results:
- 197 BCCs from 181 patients (80 female, 101 male); mean age: 64.11 (males), 59.33 (females).
- Common subtypes: nodular (45.17%), mixed (22.33%), infiltrative (15.22%).
- Most tumors (91.84%) located on head/neck; positive surgical margins in 17.7% of cases, highest for infiltrative type (43.3%).
Conclusions:
- BCC subtypes demonstrate variations in distribution, age, sex, invasion depth, and size.
- Infiltrative BCCs show higher rates of positive surgical margins and recurrence.
- Tumor location, size, and invasion depth impact recurrence risk, particularly in challenging anatomical sites.
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