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Solid-state characterization of nevirapine.
Mahua Sarkar1, O P Perumal, R Panchagnula
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Sector 67, S. A. S Nagar-160 062, India.
Indian Journal of Pharmaceutical Sciences
|March 12, 2011
Summary
This study characterized nevirapine solid-state properties. Recrystallization yielded different crystal habits but not new polymorphs, with compression influencing crystal form and desolvation.
Area of Science:
- Pharmaceutical Sciences
- Solid-State Chemistry
Background:
- Nevirapine is a crucial antiretroviral medication.
- Understanding its solid-state properties is vital for formulation and bioavailability.
Purpose of the Study:
- To characterize nevirapine from commercial and recrystallized samples.
- To investigate the impact of crystallization conditions and compression on its solid-state behavior.
Main Methods:
- Solid-state characterization using microscopy, DSC, TGA, FTIR, and PXRD.
- Dissolution studies at varying pH and particle sizes.
- Analysis of recrystallized samples from different solvent systems.
Main Results:
- Commercial nevirapine exhibited a consistent polymorphic form and anhedral habit.
- Recrystallization yielded varied crystal habits and weak solvates, but no new polymorphs.
- Dissolution rates were pH-dependent and affected by crystallization and compression.
Conclusions:
- Nevirapine's solid-state properties are sensitive to crystallization and compression.
- Compression can induce desolvation and polymorphic conversion.
- Amorphous nevirapine shows slightly enhanced aqueous solubility compared to the crystalline form.
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