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Related Concept Videos

Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: Jun 3, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Crude drugs as anticancer agents.

Xiaoyang Mou, Santosh Kesari, Patrick Y Wen

    International Journal of Clinical and Experimental Medicine
    |March 12, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Crude drugs show promise in cancer therapy and prevention, offering potential nutritional benefits. Further research is needed to fully understand their mechanisms against cancer.

    Keywords:
    Crude drugapoptosiscancercell cycleinflammation

    Related Experiment Videos

    Last Updated: Jun 3, 2026

    Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
    15:04

    Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

    Published on: January 19, 2019

    Area of Science:

    • Oncology
    • Pharmacology
    • Natural Products Chemistry

    Background:

    • Cancer remains a leading global cause of death despite advances in treatment.
    • Complex etiopathogenesis involves genetic, environmental, lifestyle, and toxin factors.
    • Current cancer therapies like chemotherapy have limitations and severe side effects.

    Purpose of the Study:

    • To review current literature on crude drugs for cancer therapy and chemo-prevention.
    • To highlight the beneficial roles and potential drug targets of crude drugs.
    • To explore the nutriceutical effects of crude drugs in cancer patients.

    Main Methods:

    • Literature review of existing studies on crude drugs in cancer research.
    • Analysis of pharmacological mechanisms and biochemical roles.
    • Focus on therapeutic applications and chemo-preventive strategies.

    Main Results:

    • Crude drugs are being investigated for their roles in cancer treatment and prevention.
    • Potential nutriceutical effects of crude drugs on cancer patients are recognized.
    • Specific drug targets and pharmacological actions are under investigation.

    Conclusions:

    • Crude drugs represent a promising area for novel cancer therapies and chemo-prevention.
    • Understanding their mechanisms is crucial for optimizing their use in oncology.
    • Further research is warranted to elucidate their full potential in combating cancer.