Multimodality molecular imaging of CD105 (Endoglin) expression.

Area of Science:

• Oncology
• Molecular Imaging
• Biomedical Engineering

Background:

• Tumor growth heavily relies on angiogenesis.
• CD105 (endoglin) is vital for endothelial cell proliferation.
• CD105 staining for microvessel density is a standard prognostic factor in solid tumors.

Purpose of the Study:

• To review advancements in multimodality molecular imaging of CD105 expression in tumor angiogenesis.
• To highlight the potential of non-invasive CD105 imaging for cancer diagnosis and treatment monitoring.

Main Methods:

• Review of targeted contrast-enhanced ultrasound.
• Review of molecular magnetic resonance imaging.
• Review of near-infrared fluorescence, SPECT, and PET imaging.

Main Results:

• Non-invasive imaging of CD105 expression has been achieved across various molecular imaging modalities.
• Despite being understudied, CD105 imaging shows promise for non-invasive assessment.

Conclusions:

• Molecular imaging of CD105 expression is critical for understanding and monitoring tumor angiogenesis.
• Future research should focus on quantitative imaging, novel imaging agents, and nanotechnology for enhanced CD105 visualization.