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MTHFR C677T polymorphism as a risk factor for vascular calcification in chronic hemodialysis patients

So-Young Lee1, Hoe-Young Kim, Kyung Mi Park

  • 1Department of Internal Medicine, Bundang CHA General Hospital, College of Medicine, CHA University, 59 Yatap-ro, Bundang, Seongnam, Korea.

Journal of Korean Medical Science
|March 12, 2011
PubMed

Insights

The MTHFR C677T gene variant is linked to increased vascular calcification (VC) in chronic hemodialysis patients. This polymorphism may be a risk factor for VC, impacting patient outcomes.

Area of Science:

  • Genetics and Molecular Biology
  • Nephrology and Urology
  • Cardiovascular Diseases

Background:

  • 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is a potential risk factor for atherosclerosis.
  • Limited research exists on the association between MTHFR C677T polymorphism and vascular calcification (VC) in patients undergoing chronic hemodialysis.

Purpose of the Study:

  • To investigate the relationship between the MTHFR C677T polymorphism and the degree of VC in chronic hemodialysis patients.
  • To assess the association of MTHFR C677T genotypes with peripheral vascular disease and cerebrovascular accidents in this patient cohort.

Main Methods:

  • Genotyping for the MTHFR C677T polymorphism was performed in 152 chronic hemodialysis patients.
  • Vascular calcification (VC) scores were evaluated and compared across different MTHFR genotypes (CC, CT, TT).
  • Prevalence of peripheral vascular disease and cerebrovascular accidents were analyzed in relation to MTHFR genotypes.

Main Results:

  • Patients with the TT genotype showed significantly higher VC scores compared to CC and CT genotypes (P = 0.002).
  • The incidence of peripheral vascular disease was higher with MTHFR C677T mutations across all patients.
  • Younger patients (≤ 60 yr) with MTHFR mutations had an increased incidence of cerebrovascular accidents. Adjusted odds ratios for VC were 1.39 for CT and 1.58 for TT genotypes.

Conclusions:

  • The MTHFR C677T polymorphism is associated with an increased degree of vascular calcification in chronic hemodialysis patients.
  • This genetic variation may serve as a risk factor for VC and related vascular complications in this population.

Keywords:
HomocysteineMethylenetetrahydrofolate Reductase (MTHFR)Renal DialysisVascular Calcification

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