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Related Experiment Video

Updated: Jun 3, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Cyclophosphamide in steroid-dependent nephrotic syndrome.

Sonia Azib1, Marie Alice Macher, Theresa Kwon

  • 1Pediatric Nephrology Department, Assistance Publique-Hôpitaux de Paris, Université Paris 7, Hôpital Robert Debré, Paris, France. sonia.azib@ch-pontoise.fr

Pediatric Nephrology (Berlin, Germany)
|March 12, 2011
PubMed
Summary

Cyclophosphamide (CPO) effectively treats steroid-dependent nephrotic syndrome (SDNS), with 57% achieving remission in one year. Optimal results were seen in children over 7.5 years old, indicating CPO

Related Experiment Videos

Last Updated: Jun 3, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Area of Science:

  • Pediatric Nephrology
  • Clinical Pharmacology

Background:

  • Steroid-dependent nephrotic syndrome (SDNS) often requires long-term immunosuppression.
  • Identifying effective and safe second-line therapies for SDNS is crucial.

Purpose of the Study:

  • To evaluate the long-term efficacy and safety of a single oral cyclophosphamide (CPO) course in SDNS patients.
  • To identify predictors of sustained remission after CPO treatment.

Main Methods:

  • Retrospective analysis of 90 SDNS patients treated with a single course of oral CPO (2 mg/kg/day for 10-12 weeks).
  • Median follow-up of 5.5 years post-CPO.
  • Analysis of remission rates, relapse data, and side effects.

Main Results:

  • Sustained remission rates were 57% at 1 year, 42% at 2 years, and 31% at 5 years.
  • Younger age at CPO initiation was linked to lower sustained remission rates (p<0.001).
  • 60% of patients did not require further immunosuppressive agents; side effect incidence was low.

Conclusions:

  • A short course of oral cyclophosphamide is an effective second-line therapy for SDNS.
  • Optimal efficacy of CPO was observed in children older than 7.5 years.
  • CPO can lead to sustained remission and reduce the need for other immunosuppressants in SDNS.