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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

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Related Experiment Video

Updated: Jun 3, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

CKD-MBD after kidney transplantation.

Katherine Wesseling-Perry1, Justine Bacchetta

  • 1Department of Pediatrics, David Geffen School of Medicine at UCLA, A2-383 MDCC, 650 Charles Young Drive, Los Angeles, CA 90095, USA. kwesseling@mednet.ucla.edu

Pediatric Nephrology (Berlin, Germany)
|March 12, 2011
PubMed
Summary

Pediatric kidney transplant recipients often have persistent bone disease. Current bone density scans like DXA are unreliable; advanced imaging shows promise for assessing bone health in these patients.

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Area of Science:

  • Nephrology
  • Pediatric Endocrinology
  • Radiology

Background:

  • Kidney transplantation improves metabolic issues in children but skeletal and cardiovascular problems persist.
  • Bone disease, including turnover, mineralization, and strength, requires evaluation in pediatric CKD patients per KDIGO guidelines.
  • Altered bone turnover and mineralization are common post-transplant, with poor correlation to biochemical markers.

Purpose of the Study:

  • To review the challenges in assessing bone disease in pediatric kidney transplant recipients.
  • To evaluate the limitations of current bone density assessment tools.
  • To explore the potential of advanced imaging techniques for bone health evaluation.

Main Methods:

  • Literature review of studies on bone disease after kidney transplantation in children.
  • Analysis of current recommendations (KDIGO) for bone disease evaluation.
  • Discussion of limitations of Dual energy X-ray absorptiometry (DXA) scanning.
  • Exploration of newer imaging modalities like quantitative CT (QCT) and MRI.

Main Results:

  • Bone turnover and mineralization are frequently altered post-transplant, and biochemical markers are poor predictors of bone histology.
  • Dual energy X-ray absorptiometry (DXA) has limitations in pediatric transplant patients and does not correlate with fracture risk.
  • Advanced imaging techniques (CT, MRI) offer volumetric assessment and bone microarchitecture evaluation, showing promise for bone strength assessment.

Conclusions:

  • Bone disease remains a significant issue in pediatric kidney transplant recipients.
  • DXA is not recommended for assessing bone density in this population.
  • Newer imaging techniques hold promise for diagnosing and managing renal osteodystrophy, but further research is needed.