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Related Experiment Video

Updated: Jun 3, 2026

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
06:48

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Intraocular delivery of recombinant virus.

F Q Liang1, V Anand, A M Maguire

  • 1Chance Labs, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA.

Methods in Molecular Medicine
|March 12, 2011
PubMed
Summary

Recent technological advances enable efficient in vivo gene transfer to eye cells using viral vectors. This progress supports the experimental use of gene therapy for retinal diseases like retinitis pigmentosa in animal models.

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Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Biotechnology

Background:

  • Technological advancements have enabled efficient in vivo somatic gene transfer to ocular cells.
  • Viral vectors, modified to carry therapeutic genes, are key to this progress.

Purpose of the Study:

  • To review the advancements in gene therapy for ocular diseases.
  • To highlight the potential of viral vectors in treating retinal conditions.

Main Methods:

  • Development and refinement of viral vector technology for gene delivery.
  • Utilizing viral vectors for experimental gene transfer in ocular tissues.

Main Results:

  • Efficient somatic gene transfer to target eye cells in vivo is now achievable.

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Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models

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Last Updated: Jun 3, 2026

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
06:48

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Intravitreal Injections in the Ovine Eye
03:37

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models
06:16

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models

Published on: March 16, 2022

  • Proof-of-principle for virus-based retinal gene therapy demonstrated in animal models for retinitis pigmentosa.

    • Conclusions:

    • The field has advanced from demonstrating feasibility to utilizing gene transfer for therapeutic purposes.
    • Viral vector-based gene therapy shows promise for treating inherited retinal diseases.