Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Significance of histocompatibility tests].

F Nishigaki1, M Nozaki, A Nakamura

  • 1Department of Central Laboratories, Sapporo City General Hospital.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|February 1, 1990
PubMed
Summary

Pretransplant tests like HLA typing and mixed lymphocyte culture response (MLR) improve kidney graft survival. Post-transplant monitoring for anti-donor antibodies aids in early rejection detection and prognosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One of the rubber latex allergens is a lysozyme.

The Journal of allergy and clinical immunology·1995
Same author

Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions.

Gastroenterology·1995
Same author

[Usefulness of 3-dimensional image analysis of skull base lesions].

No shinkei geka. Neurological surgery·1995
Same author

[Efficacy and complications of topical cocaine anesthesia in functional endoscopic sinus surgery].

Nihon Jibiinkoka Gakkai kaiho·1995
Same author

Purification of an ATP-dependent actin-binding protein from a lower eukaryote, Physarum polycephalum.

Biochemical and biophysical research communications·1995
Same author

[A case of myelodysplastic syndrome who died of septic pulmonary embolism].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·1995

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation

Context:

  • Kidney transplantation requires pretransplant assessments including HLA typing, mixed lymphocyte culture response (MLR), and direct crossmatch.
  • HLA matching and MLR are critical for predicting graft survival rates.
  • Warm T crossmatch is performed to prevent hyperacute or accelerated graft rejection, with positive rates influenced by blood transfusions.

Purpose:

  • To evaluate the impact of HLA matching and MLR on kidney graft survival.
  • To assess the prevalence of warm T antibodies in hemodialysis patients and their relation to transfusion history.
  • To determine the necessity and utility of post-transplant crossmatches and compare the sensitivity of flow cytometry crossmatches with standard cytotoxicity tests.

Summary:

Related Experiment Videos

  • Analysis of 25 living related kidney grafts showed higher survival rates with two versus one haplotype-identical donor.
  • Graft survival rates correlated with MLR response levels, with lower rejection rates in the low response group.
  • Warm T antibody positivity was observed in 13.0% of 239 hemodialysis patients, increasing with transfusion history.
  • Post-transplant crossmatches are vital for early detection, diagnosis, and prognosis of rejection.
  • Flow cytometry crossmatches demonstrated significantly higher sensitivity compared to standard cytotoxicity tests.

    • Impact:

    • HLA typing and MLR are valuable tools for recipient selection in kidney transplantation.
    • Understanding warm T antibody prevalence and crossmatch outcomes can optimize transplant strategies.
    • Post-transplant monitoring and advanced crossmatch techniques like flow cytometry enhance graft surveillance and patient outcomes.