Related Experiment Video
Updated: Jun 3, 2026
08:51
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
A measurement setup for direct 17O MRI at 7 T.
Stefan H Hoffmann1, Paul Begovatz, Armin M Nagel
1Department of Medical Physics in Radiology, German Cancer Research Center (dkfz), Heidelberg, Germany.
Magnetic Resonance in Medicine
|March 12, 2011
Summary
A novel breathing system enables direct oxygen-17 MRI for brain metabolism studies. This efficient system maximizes the use of rare oxygen-17 gas, revealing regional brain oxygen concentration variations.
Area of Science:
- Medical Imaging
- Physiology
- Biochemistry
Background:
- Direct (17)O MRI is a powerful tool for studying human brain oxygen metabolism.
- Efficient delivery and utilization of the rare isotope oxygen-17 ((17)O) are critical for successful studies.
Purpose of the Study:
- To design and validate an efficient breathing system for direct (17)O MRI.
- To enable precise measurement of oxygen metabolism in the human brain using (17)O MRI.
Main Methods:
- A custom breathing system with a demand oxygen delivery device and a re-breathing circuit was developed.
- Short gas pulses of enriched (17)O(2) were delivered via nasal cannula triggered by inspiration.
- Direct (17)O MRI was performed on a healthy volunteer with a temporal resolution of 50 s.
Main Results:
- The system efficiently delivered (17)O(2) to the lungs, minimizing gas waste.
- Regional variations in oxygen concentration of up to 30% were observed compared to natural abundance.
- Direct (17)O MRI successfully mapped oxygen concentration changes in the brain.
Conclusions:
- The developed breathing system is effective for direct (17)O MRI studies of brain oxygen metabolism.
- This technology allows for detailed investigation of regional oxygen dynamics in the brain.
- Efficient use of (17)O gas is crucial for advancing metabolic imaging research.
More Related Videos
Related Concept Videos
01:24Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
01:27Imaging Studies IV: Magnetic Resonance Imaging
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...