Related Experiment Video
Updated: Jun 3, 2026
12:52
Iridium(III) Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
Visible light-triggered photoswitchable diarylethene-based iridium(III) complexes for imaging living cells
Wenjuan Tan1, Jing Zhou, Fuyou Li
1Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science &Technology, Shanghai 200237, China.
Chemistry, an Asian Journal
|March 12, 2011
Summary
Researchers developed a new iridium(III) complex as a phosphorescence probe for living cells. This probe
Area of Science:
- Materials Science
- Biochemistry
- Analytical Chemistry
Background:
- Phosphorescence probes are crucial for real-time biological monitoring.
- Developing probes with controllable emission and low photodamage is essential for live-cell imaging.
Purpose of the Study:
- To synthesize and characterize a novel diarylethene-based iridium(III) complex for live-cell monitoring.
- To investigate the switchable phosphorescence properties of the complex under visible light.
- To evaluate its potential as a probe with minimal photodamage.
Main Methods:
- Synthesis of a diarylethene-based iridium(III) complex.
- Spectroscopic analysis of the complex's phosphorescence.
- Demonstration of light-controlled switching of phosphorescence in solution.
- Application of the probe in monitoring living cells with visible-light irradiation.
Main Results:
- A novel diarylethene-based iridium(III) complex was successfully synthesized.
- The complex exhibited switchable phosphorescence controllable by two distinct visible-light wavelengths.
- The probe demonstrated effective monitoring of living cells with visible-light control.
- The complex showed potential for low photodamage in biological samples.
Conclusions:
- The synthesized iridium(III) complex functions as a switchable phosphorescence probe.
- Visible-light-controlled switching offers precise manipulation for cellular monitoring.
- This probe shows promise for advanced live-cell imaging with reduced photodamage.
