[Vegetative disbalance in pathogenesis of metabolic syndrome]

The aim of the work was to elucidate peculiarities of neurovegetative mechanisms underlying cardiovascular regulation in patients with metabolic syndrome (MS) compared with healthy subjects and patients with arterial hypertension (AH). 46 patients presented with AH without obesity and metabolic disturbances, 42 with MS. 24-hour AD and ECG monitoring was performed and cardiac rhythm variability indices (CVI) were calculated. AH patients showed lowered CVI in association with decreased high-frequency vagal effects compared with healthy subjects. MS patients had smaller CVI than healthy and AH ones due to much poorer involvement of both parasympathetic and sympathetic divisions of vegetative nervous system. Vegetative balance index remained normal. It is concluded that the use of LF/HF ratio alone is insufficient for the evaluation of sympatovagal index in MS patients due to markedly decreased CVI; a complex analysis of all CVI temporal and spectral characteristics is needed.