Related Experiment Video

Updated: Jun 3, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Reduced glomerular filtration rate as a marker of cardiovascular risk in the general population]

N A Mukhin, S V Moiseev, V V Fomin

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |March 15, 2011
    PubMed

    Insights

    Stable reduction in glomerular filtration rate indicates increased cardiovascular risk. This finding highlights its importance as a prognostic marker for heart health.

    Area of Science:

    • Nephrology
    • Cardiology
    • Clinical Medicine

    Context:

    • Glomerular filtration rate (GFR) is a key indicator of kidney function.
    • Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
    • Understanding novel risk markers for CVD is crucial for preventative strategies.

    Purpose:

    • To discuss the clinical and prognostic significance of a stable reduction in glomerular filtration.
    • To evaluate the utility of stable reduced GFR as a marker for cardiovascular risk.
    • To explore the implications of this marker in patient management and outcomes.

    Summary:

    • A stable decline in glomerular filtration rate (GFR) is clinically significant.
    • This stable reduction in GFR serves as a prognostic marker for cardiovascular risk.
    • The findings underscore the link between kidney function decline and heart health.

    Impact:

    • Provides insights into using stable GFR reduction for cardiovascular risk stratification.
    • May inform clinical guidelines for managing patients with declining kidney function.
    • Contributes to a better understanding of the interplay between renal and cardiovascular health.

    More Related Videos

    A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice07:07

    A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

    Published on: May 10, 2013

    Related Concept Videos

    Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

    Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

    The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

    Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
    Glomerular Filtration Rate and its Regulation01:28

    Glomerular Filtration Rate and its Regulation

    The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
    GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
    The myogenic...
    Factors Affecting Renal Clearance: Renal Impairment01:17

    Factors Affecting Renal Clearance: Renal Impairment

    Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
    One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
    Renal Drug Excretion: Glomerular Filtration01:02

    Renal Drug Excretion: Glomerular Filtration

    The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
    Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
    Renal Clearance01:23

    Renal Clearance

    The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
    Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...