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Updated: Jun 3, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Influence of FGF2 level on the inflammation phase dynamics at the postinfarction cardiosclerosis]
Abstract:
We modeling myocardial infarction female Wistar rats (N=126). We used morphomethry for examination of infarction zone from 2 h to 30 days after operation. The study comprised three groups of animals: "Control", "FGF" with 100 Hz FCGF2 injection into left ventricle, "anti-FGF" with 2 microg monoclonal antiFCF2 antibodies injections at period 1.5 h, 6 h and 3 day after operation. We founded that FCF2 injections leaded to enlarged of infiltrative inflammatory stage and take effect on the early collagen synthesis in infarction regions (from 3 days in group with FGF2 injection vs. 7 days in control group). Opportunity,injection of anti-FCF2 antibodies leaded to decreasing collagen volume on 30 day after infarction (19.15 +/- 1.22% in "anti-FGF" group vs. 41.71 +/- 1.30% in "Control" group, p < 0.05).
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