[The correlation between the expression of AQP1 and angiogenesis ability in nasopharyngeal carcinoma]

To investigate the expression and correlation of Aquaporin-1 (AQP1), VEGF and MVD in nasopharyngeal tumor and non-tumor tissues.

Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative PCR (RT-PCR) to detect the expression level of AQP1 and VEGF in tissues. MVD were then calculated.

Both immunohistochemistry and RT-PCR showed higher expression of AQP1 and VEGF in tumor tissues than in non-tumor tissues. The two factors were positively correlated.

In nasopharyngeal carcinoma, AQP1 may participate in angiogenesis by VEGF. Thus it may facilitate the tumor's growing and metastasis.