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Updated: Jun 3, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cerium ammonium nitrate-catalyzed multicomponent reaction for efficient synthesis of functionalized
Hong-Juan Wang1, Li-Ping Mo, Zhan-Hui Zhang
1The College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang, China.
Abstract:
A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a multicomponent condensation reaction of β-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of cerium ammonium nitrate (CAN) is reported. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to good yields at room temperature.
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