Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more effectively...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Physicochemical Characterization and Release Kinetics of an Astaxanthin Nanoplex: Integrated <i>In Silico</i> and <i>In Vitro</i> Evaluation.

Assay and drug development technologies·2026
Same author

Gut microbiota: The hidden hallmark of aging.

Acta microbiologica et immunologica Hungarica·2026
Same author

Development and evaluation of sorafenib and curcumin co-loaded microemulsion gel for the management of breast cancer.

Journal of pharmaceutical sciences·2026
Same author

Corrigendum to "Gene therapy for diabetic wound healing: mechanistic pathways, therapeutic gene targets, and advances in viral and non-viral delivery systems" [Int. J. Pharm. 696 (2026) 126815].

International journal of pharmaceutics·2026
Same author

Engineering Peptide-Based Hydrogels: Smart Therapeutic Platforms for Inflammatory Disorders.

ACS biomaterials science & engineering·2026
Same author

Gene therapy for diabetic wound healing: mechanistic pathways, therapeutic gene targets, and advances in viral and non-viral delivery systems.

International journal of pharmaceutics·2026

Related Experiment Video

Updated: Jun 3, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Novel dithranol phospholipid microemulsion for topical application: development, characterization and percutaneous

Kaisar Raza1, Poonam Negi, Shweta Takyar

  • 1Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India.

Journal of Microencapsulation
|March 15, 2011
PubMed
Summary

This study developed novel dithranol phospholipid microemulsions for better skin delivery. The optimized isopropyl myristate and Tween 80 system significantly enhanced dithranol skin permeation and retention.

More Related Videos

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Related Experiment Videos

Last Updated: Jun 3, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

  • Pharmaceutical Sciences
  • Dermatology
  • Materials Science

Background:

  • Dithranol is a key therapeutic agent for skin conditions, but its topical delivery is challenging.
  • Developing effective delivery systems is crucial for maximizing dithranol's therapeutic potential.
  • Microemulsions offer a promising vehicle for enhancing drug permeation and retention in the skin.

Purpose of the Study:

  • To formulate and characterize novel dithranol-loaded phospholipid microemulsions.
  • To evaluate the impact of different oil and surfactant combinations on microemulsion properties.
  • To assess the ex vivo skin permeation and retention of dithranol from the developed systems.

Main Methods:

  • Formulation of dithranol microemulsions using isopropyl myristate (IPM) or tocopherol acetate (TA) as oils and Tween 80 (T80) or Tween 20 (T20) as surfactants.
  • Phase diagram construction to identify stable microemulsion regions.
  • Characterization of microemulsions for globule size, zeta potential, viscosity, and stability.
  • Ex vivo skin permeation and retention studies using Franz diffusion cells.

Main Results:

  • Microemulsions composed of IPM and T80 exhibited optimal characteristics, with a mean particle diameter of 72.8 nm.
  • These IPM/T80 microemulsions demonstrated superior performance, achieving 82.23% skin permeation and 8.31% skin retention.
  • The optimized system showed a high permeation flux of 0.281 mg/cm²/h, outperforming systems with TA and T20.

Conclusions:

  • Novel lecithinized microemulsion systems effectively enhance dithranol's topical delivery.
  • The IPM and T80-based microemulsion formulation shows significant potential for improved skin permeation and retention of dithranol.
  • These findings support the development of advanced microemulsion-based therapies for dermatological applications.