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Published on: December 14, 2016
Discovery of novel methanone derivatives acting as antimycobacterial agents
Mohamed Ashraf Ali1, Sylvaine Bastian, Rusli Ismail
1Pharmacogenetic and Novel Therapeutics Research, Institute for Research in Molecular Medicine, Universiti of Sains Malaysia, Pennag, Malaysia. asraf80med@rediffmail.com
Abstract:
A series of pyrazoline derivatives were synthesized and in vitro activity against Mycobacterium tuberculosis H37Rv was carried out. Among the synthesized compounds, compounds (4d) and (4f) 4-aminophenyl-3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone and 4-aminophenyl-6,7-dimethoxy-3-phenyl-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone were found to be the most active agent against M. tuberculosis H37Rv with a minimum inhibitory concentration of 10 μg/mL.
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