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Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
Published on: November 1, 2024
The pathogenesis and treatment of acne
1Department of Dermatology, Boston University School of Medicine, Massachusetts 02118.
Abstract:
Acne is a follicular disorder of the skin occurring in specialized pilosebaceous units on the face and trunk. An abnormality of the keratinizing epithelium of these follicles, thought to be due to the action of sebum synthesized and secreted by the androgen-sensitive sebaceous glands, leads to inflammation induced by the follicular bacterium, Propionibacterium acnes. Therapy involves treatments that modify these pathogenic factors and includes drugs with antikeratinizing, antibacterial, and antiseborrheic actions.
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