Oculogyric crises secondary to lamotrigine overdosage

Area of Science:

• Neurology
• Clinical Pharmacology

Background:

• Oculogyric crises are rare but serious adverse events.
• Lamotrigine is an anticonvulsant medication with a known side effect profile.

Purpose of the Study:

• To report cases of oculogyric crises associated with lamotrigine toxicity.
• To investigate the relationship between lamotrigine dosage and oculogyric crises.

Main Methods:

• Retrospective case series of four patients.
• Analysis of lamotrigine plasma concentrations and dosages.
• Clinical observation of oculogyric crisis resolution after dose adjustment.

Main Results:

• Four patients developed oculogyric crises without prior movement disorders.
• Crises resolved after reducing lamotrigine dosage.
• Mean lamotrigine plasma concentration was 15.5 μg/mL at crisis onset.

Conclusions:

• Lamotrigine toxicity is a potential cause of oculogyric crises.
• Dose reduction of lamotrigine can effectively manage these crises.