Related Experiment Video
Updated: Jun 3, 2026

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice
Published on: March 31, 2015
Adult neurogenesis and the plasticity of the dentate gyrus network
Lucas A Mongiat1, Alejandro F Schinder
1Laboratory of Neuronal Plasticity, Leloir Institute - CONICET, Buenos Aires, Argentina.
Abstract:
The granule cell layer (GCL) of the dentate gyrus contains neurons generated during embryonic, early postnatal and adult life. During adulthood there is a continuous production of neuronal cohorts that develop and functionally integrate in the preexisting circuits. This morphogenic process generates a stratified GCL, with the outermost layers containing dentate granule cells (DGCs) generated during perinatal life, and the innermost layers containing adult-born DGCs. In this review we analyse the functional profile of the different neuronal populations of the GCL, with an emphasis on adult-born neurons as they develop, mature and integrate in the dentate gyrus network. We focus on the contribution of adult-born neurons to activity-dependent synaptic modification in the dentate gyrus and, in turn, discuss how network activity modulates integration and survival of new neurons.
More Related Videos
Related Concept Videos
Neuroplasticity
Neurogenesis and Regeneration of Nervous Tissue
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...

