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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...

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Related Experiment Video

Updated: Jun 3, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

MicroRNAs and cardiovascular diseases.

Koh Ono1, Yasuhide Kuwabara, Jiahuai Han

  • 1Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. kohono@kuhp.kyoto-u.ac.jp

The FEBS Journal
|March 15, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key gene regulators found to be altered in heart disease. This review summarizes current findings on their roles and targets in cardiac conditions.

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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Related Experiment Videos

Last Updated: Jun 3, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Area of Science:

  • Biochemistry and Molecular Biology
  • Genetics and Genomics
  • Cardiovascular Biology

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression.
  • Aberrant miRNA expression is observed in cardiovascular pathologies.
  • Specific miRNAs play critical roles in cardiovascular development and function.

Purpose of the Study:

  • To update current findings on the role of miRNAs in cardiac diseases.
  • To summarize known miRNA targets in the context of cardiovascular conditions.

Main Methods:

  • Literature review of recent studies on miRNAs in cardiac diseases.
  • Analysis of gain- and loss-of-function studies in vitro and in vivo.
  • Compilation of data on specific miRNA roles and their target genes.

Main Results:

  • miRNAs are increasingly recognized for their implications in cardiovascular disease.
  • Distinct miRNAs have specific functions in cardiac physiology and pathology.
  • Research in this field is rapidly evolving.

Conclusions:

  • miRNAs are significant players in the pathogenesis of cardiac diseases.
  • Understanding miRNA-target interactions is crucial for developing new therapeutic strategies.
  • Further research is warranted to fully elucidate the therapeutic potential of miRNAs in cardiology.