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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
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Published on: January 4, 2015

Neuroprotective features of mesenchymal stem cells.

Antonio Uccelli1, Federica Benvenuto, Alice Laroni

  • 1Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy. auccelli@neurologia.unige.it

Best Practice & Research. Clinical Haematology
|March 15, 2011
PubMed
Summary

Bone marrow mesenchymal stem cells (MSC) show neuroprotective effects by reducing inflammation and promoting neural repair. These cells offer therapeutic potential for neurological conditions like multiple sclerosis and brain injury.

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Last Updated: Jun 3, 2026

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09:19

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08:18

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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)

Published on: December 24, 2015

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Mesenchymal stem cells (MSC) from bone marrow (BM) can differentiate into neural and glial cells.
  • MSC possess anti-proliferative, anti-inflammatory, and anti-apoptotic properties, enhancing their therapeutic potential.
  • MSC have shown efficacy in animal models of neurological diseases, including experimental autoimmune encephalomyelitis (EAE), brain ischemia, and spinal cord injury.

Purpose of the Study:

  • To review the mechanisms and targets of neuroprotection mediated by bone marrow-derived mesenchymal stem cells (BM-MSC).
  • To highlight the therapeutic potential of BM-MSC in neurological disorders.

Main Methods:

  • Review of experimental studies investigating BM-MSC in animal models of neurological diseases.
  • Analysis of paracrine mechanisms involved in BM-MSC neuroprotection, including growth factor release and cytokine modulation.

Main Results:

  • BM-MSC administration resulted in significant neuroprotection and rescue of neural cells in experimental models.
  • Therapeutic effects are attributed to paracrine mechanisms, fostering neurogenesis, remyelination, and improved cerebral blood flow.
  • BM-MSC demonstrated effectiveness in inhibiting autoimmune responses in EAE models.

Conclusions:

  • BM-MSC offer significant neuroprotective benefits through paracrine signaling.
  • Their ease of culture, expansion under GMP conditions, and low risk of malignant transformation make them promising for clinical applications in neurodegenerative diseases and injury recovery.