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Updated: Jun 3, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
[Orbital and nasal complications secondary to inhaled cocaine abuse]
Purificación Contreras Molina1, Eva Flores Carmona, Carlos Alberto Muñoz Palza
1Servicio de Otorrinolaringología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, España. puricontri@hotmail.com
Abstract:
The abuse of inhaled cocaine causes chemical sinus pathology by secondary midfacial destruction and necrosis. When midfacial necrosis is already established, other complications may occur related to the proximity of structures such as the orbit or optic nerve. We present the evolution of a young cocaine addict with midfacial destruction, who has had a subperiosteal abscess and optic neuritis over the course of the years. Differential diagnosis and management of these complications are also discussed.
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