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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

[Persistent polyclonal B-cell lymphocytosis: study of 35 cases].

Lourdes Florensa1, José Tomás Navarro, María Encarnación Pérez Vila

  • 1Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, Barcelona, España. lflorensa@imas.imim.es

Medicina Clinica
|March 15, 2011
PubMed
Summary

Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare condition in women, often smokers, with stable, asymptomatic evolution despite genetic abnormalities. Further study is needed to determine if it is premalignant.

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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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Published on: October 19, 2014

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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Context:

  • Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare hematologic disorder.
  • It predominantly affects adult women who smoke.
  • PPBL is characterized by increased serum IgM, HLA-DR7 haplotype, and genetic abnormalities.

Purpose:

  • To analyze the characteristics of PPBL.
  • To investigate the clinical evolution of PPBL.
  • To determine if PPBL is a benign or premalignant condition.

Summary:

  • A retrospective analysis of 35 PPBL patients was conducted.
  • Morphologic, clinical, and biological data were analyzed.
  • The study found PPBL has a stable, asymptomatic course with frequent genetic abnormalities.

Impact:

  • PPBL exhibits a stable, asymptomatic evolution in most cases.
  • Genetic abnormalities are common in PPBL.
  • Accurate diagnosis and follow-up are crucial for managing PPBL, though its premalignant potential remains uncertain.