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Crystal structure of human enterovirus 71 3C protease

Sheng Cui1, Jing Wang, Tingting Fan

  • 1State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China. cuisheng2007@yahoo.com.cn

Journal of Molecular Biology
|March 15, 2011
PubMed
Summary

Human enterovirus 71 (EV71) causes hand, foot, and mouth disease. This study reveals the first crystal structure of EV71 3C protease, identifying a mobile beta-ribbon crucial for its activity and potential drug targeting.

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